From her introduction to television as Lisa E on MTV's "Awake on the Wild Side" to her role as "Dr. Lisa Cuddy" on HOUSE, Lisa Edelstein is no stranger to fearless roles. In the past several years, Edelstein has portrayed Rob Lowe's call-girl girlfriend on "The West Wing," the transsexual boyfriend of James LeGros on "Ally McBeal," David Conrad's lesbian sister on "Relativity," an Orthodox Jew losing custody of her child on "Family Law" and James Spader's love interest on "The Practice."

Additional television credits include her series regular role on "Leap of Faith" and guest turns on "Seinfeld," "Without a Trace," "Frasier," "Felicity" and "ER." Edelstein also works extensively in the realm of voiceover, most recently as "Mercy Graves" on the animated "Superman" and "Justice League" series as well as guest spots on AMERICAN DAD and KING OF THE HILL.

In feature films, Edelstein starred as Ben Stiller's aerobics-obsessed date in "Keeping the Faith." Additional credits include "What Women Want," "Daddy Day Care," "As Good As It Gets" and the comedies "Say Uncle" and "Grilled." She also starred in the dramatic cable feature "Fathers and Sons."

After honing her craft at NYU's Tisch School of the Arts, Edelstein performed in numerous off- and off-off-Broadway productions, including the AIDS-related musical "Positive Me," which she authored, composed and performed.

Edelstein lives in Los Angeles in a century-old home with her cat and rescue dogs. She is an avid practitioner of Ashtanga Yoga and volunteers her time by working with the Best Friends Animal Sanctuary, Save the Children, Planned Parenthood and AmFAR.